Design of a 350 kW DC/DC Converter in 1200-V SiC Module Technology for Automotive Component Testing

In this paper, the design and implementation of a DC/DC converter for automotive component testing with state-of-the art performance is described. The converter is the core of a battery emulator for the characterization and development of automotive batteries, electronic chargers, traction inverters, DC-DC converters, E-motors and E-axles. Cutting edge performance, flexibility and compactness are obtained by exploiting 1200-V SiC modules, high switching frequency, planar transformer technology, suitable topology solutions and fast digital control strategies. The implemented system is a liquid-cooled, bidirectional converter with galvanic isolation capable of 350 kW continuous output power, output voltage range 48-1000 V, continuous output current up to 800 A (1600 A peak), voltage/current ramp-up time below 10/2 ms and 0.1% current/voltage accuracy. The entire instrument is implemented in a standard full-height 19-inch rack cabinet

Dirac Equation-Based Formulation for the Quantum Conductivity in 2D-Nanomaterials

bstract: Starting from the four component-Dirac equation for free, ballistic electrons with finite mass, driven by a constant d.c. field, we derive a basic model of scalar quantum conductivity, capable of yielding simple analytic forms, also in the presence of magnetic and polarization effects. The classical Drude conductivity is recovered as a limit case. A quantum-mechanical evaluation is provided for parabolic and linear dispersion, as in graphene, recovering currently used expressions as particular cases. Numerical values are compared with the ones from the literature in the case of graphene under d.c. applied field

Dupilumab in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP): A multicentric observational Phase IV real-life study (DUPIREAL)

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is associated with significant morbidity and reduced health-related quality of life. Findings from clinical trials have demonstrated the effectiveness of dupilumab in CRSwNP, although real-world evidence is still limited. Methods This Phase IV real-life, observational, multicenter study assessed the effectiveness and safety of dupilumab in patients with severe uncontrolled CRSwNP (n = 648) over the first year of treatment. We collected data at baseline and after 1, 3, 6, 9, and 12 months of follow-up. We focused on nasal polyps score (NPS), symptoms, and olfactory function. We stratified outcomes by comorbidities, previous surgery, and adherence to intranasal corticosteroids, and examined the success rates based on current guidelines, as well as potential predictors of response at each timepoint. Results We observed a significant decrease in NPS from a median value of 6 (IQR 5–6) at baseline to 1.0 (IQR 0.0–2.0) at 12 months (p < .001), and a significant decrease in Sino-Nasal Outcomes Test-22 (SNOT-22) from a median score of 58 (IQR 49–70) at baseline to 11 (IQR 6–21; p < .001) at 12 months. Sniffin' Sticks scores showed a significant increase over 12 months (p < .001) compared to baseline. The results were unaffected by concomitant diseases, number of previous surgeries, and adherence to topical steroids, except for minor differences in rapidity of action. An excellent-moderate response was observed in 96.9% of patients at 12 months based on EPOS 2020 criteria. Conclusions Our findings from this large-scale real-life study support the effectiveness of dupilumab as an add-on therapy in patients with severe uncontrolled CRSwNP in reducing polyp size and improving the quality of life, severity of symptoms, nasal congestion, and smell

Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: emerging role of supracricoid partial laryngectomy

BACKGROUND: Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences of laryngeal squamous cell carcinoma (SCC) after a first attempt of organ preservation. METHODS: The clinical records of 68 consecutive patients primarily treated by irradiation or endoscopic surgery and surgically salvaged by total laryngectomy or supracricoid partial laryngectomy in 2 large university hospitals in Italy from 2004 to 2010 were reviewed. RESULTS: The survival was not affected by the primary treatment or by salvage modality. The only parameter always keeping a prognostic value is the involvement of resection margins of salvage surgery. Patients with early relapse seem to have a worse prognosis than patients with a delayed relapse (p = .05 at Cox multivariate analysis and p = .048 at Wilcoxon test for overall survival [OS] from the primary treatment). CONCLUSION: Supracricoid operations, if the indications are careful, can prove reliable salvage procedures

Oncological results of the surgical salvage of recurrent laryngeal SCC in a multicentric retrospective series. The emerging role of supracricoid partial laryngectomy

Several studies in the last decade evaluated conservative surgical procedures, and in particular supracricoid operations, as an alternative to total laryngectomy for the salvage of recurrences of laryngeal SCC after a first attempt of organ preservation

Oncologic results of the surgical salvage of recurrent laryngeal squamous cell carcinoma in a multicentric retrospective series: emerging role of supracricoid partial laryngectomy

Several studies in the last decade evaluated conservative surgical procedures and, in particular, supracricoid operations as an alternative to total laryngectomy for the salvage of recurrences of laryngeal squamous cell carcinoma (SCC) after a first attempt of organ preservation